PVP solid dispersions containing Poloxamer 407 or TPGS for the improvement of ursolic acid release

Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30 (PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or poloxamer 407 (P407) the aim enhancing solubility and vitro release UA. SDs investigated a 24 full factorial design, subsequently selected formulations characterized for water solubility, X-ray diffractometry (XRD), differential scanning calorimetry (DSC), particle diameter, electron microscopy, drug content, physical-chemical stability profile. showed higher UA water-solubility than physical mixtures (PMs), which was attributed by transition from crystalline to amorphous molecular state SDs, indicated XRD DSC analyses. SD1 (with P407) SD2 TPGS) chosen further investigation because they had load. proved be more stable SD2, revealing that P407 contributed ensure Furthermore, increased diffusion swelling-controlled transport, following Weibull model. Thus, solid obtained PVP k-30 advantageous enhance aqueous